No. 20 Penn State (5-2) suffered its second loss last week against Illinois after nine overtimes. No. 5 Ohio State (6-1) will host the Nittany Lions on Saturday at Ohio Stadium. The Buckeyes are still a perfect 4-0 in Big Ten play, but the visiting team nearly took down No. 9 Iowa on the road earlier this year and could ruin their conference winning streak.

Kickoff is set for 7:30 p.m. ET. Ohio State is favored by 19.5 points in the latest Penn State vs. Ohio State odds from Caesars Sportsbook, while the Over-Under is set at 60.5. 

Before making any Penn State vs. Ohio State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It also enters Week 9 of the 2021 season on a 26-11 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Penn State's run defense is sturdy. Only nine FBS teams have given up fewer rushing touchdowns (5) than the Nittany Lions this year. Their front line will have to be in top form to slow down the Buckeyes. The model also knows Ohio State's ground game is prolific. Buckeyes running back TreVeyon Henderson ranks third in the country with 11 rushing scores and has tallied nearly 700 yards while averaging almost nine yards per carry. The true freshman makes home-run plays consistently and has reached the end zone every game this season.

Now, it has simulated Penn State vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning under the total, and it's also generated a point-spread pick that hits in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks!

So who wins Penn State vs. Ohio State? And which side of the spread hits well over 60 percent of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.