The No. 14 Michigan Wolverines hit the road for the first time this season when they square off against the Wisconsin Badgers on Saturday at Camp Randall Stadium in Madison, Wisc. The Wolverines (4-0, 1-0 in Big Ten) are 4-0 for the first time since 2017. Like Michigan, the Badgers (1-2, 0-1) have played all of their games this season at home. 

Kickoff is noon ET. The Badgers are two-point favorites in the latest Wisconsin vs. Michigan odds from Caesars Sportsbook, while the Over/Under for total points scored is 43.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you make any Michigan vs. Wisconsin picks and college football predictions, see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

The model knows that Wisconsin has the stingiest run defense in the nation. The Badgers give up a paltry 23.0 rushing yards per game. That leads the country and is half the amount allowed by the No. 2 run defense, San Diego State (46.0). Last week against the Fighting Irish, Wisconsin allowed just three rushing yards.

The model also knows that the Michigan defense has been excellent to start the season. The Wolverines are giving up just 11.8 points per game, which ranks second in the Big Ten and fourth in the country. This is the first time that Michigan has held each of its first four opponents to 14 or fewer points since the 1997 national championship season.

Now the model has simulated Michigan vs. Wisconsin 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it has generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the battle between Wisconsin and Michigan? And which side of the spread hits in well over 60 percent of simulations? ... Join SportsLine right now to see which side of the Michigan vs. Wisconsin spread you need to jump on Saturday, all from the computer model that has crushed its college football picks!