After having their eight-game winning streak snapped on Saturday, the No. 12-ranked Duke Blue Devils will look to start a new one when they take on the Louisville Cardinals in Atlantic Coast Conference action on Tuesday night. The Blue Devils (13-4, 4-2 ACC) are 2-2 on the road, while the Cardinals (6-12, 1-6 ACC) are 5-5 on their home court. Duke is favored by 14 points in the latest Duke vs. Louisville odds, and the over/under is 149.5 points. 

Before entering any Duke vs. Louisville picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 12 of the 2023-24 season on a 114-73 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 19-5 start on top-rated spread picks this season. Anyone following has seen huge returns!

The model knows Duke sophomore center Kyle Filipowski continues to be a force in the middle. In 17 games, all starts, he is averaging 18.2 points, 8.6 rebounds, 2.9 assists, 1.9 blocks and 1.2 steals per game, and is connecting on 51.6% of his field goals, including 42.1% from 3-point range, and 69.8% at the foul line.

It is also aware sophomore guard Mike James has carried the bulk of the scoring load for the Cardinals this year. In 18 games, all starts, he is averaging 14.1 points, 5.6 rebounds and 1.3 assists in 31.9 minutes of action.

The model has simulated Duke vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under the total, and it's also generated a point-spread pick that is cashing in over 60% of simulations. 

So who wins Duke vs. Louisville, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.