Home-field advantage was very apparent last week as home teams went 13-3 against the spread. So, as you make your Week 17 NFL best bets, should you expect this trend to continue, or will the pendulum swing the other way with road teams having spread success? That's what you'll have to decide on before constructing a Week 17 NFL parlay or making football picks ATS. The three biggest favorites this Sunday are all home squads with the Bills vs. Jets (+8.5), the Buccaneers vs. Panthers (+8), and the Eagles vs. Cowboys (+7.5)

Which NFL trends and NFL betting lines could help with your NFL betting strategy? Before you make any Week 17 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 97-77-3 (+11.28 units) since its inception in 2022. Anyone who has followed him is WAY UP!

For Week 17, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Lions (-3.5, 50.5) to cover on the road versus the 49ers on Monday night. "Regardless of scenarios for the NFC North and the No. 1 seed, the Lions will bring an all-out effort in the place where their Super Bowl dreams died last season. They're getting some reinforcements back, including Graham Glasgow and Jalen Reeves-Maybin, and will be facing a depleted 49ers team that's scored 17 or fewer points in five of the past six games. Detroit averages an NFL-high 32.9 points and the 49ers won't be able to keep pace," Hartstein told SportsLine.

Hartstein also has locked in two other confident Week 17 bets, including backing a SHOCKING team versus an opponent whose "offense looks lost!" You ABSOLUTELY need to see his picks before betting on NFL Week 17.

So what are Hartstein's Week 17 NFL best bets, and which team shocks the NFL? ... Join SportsLine right now to see Larry Hartstein's Week 17 NFL best bets, all from the expert who is up 11.28 units on NFL ATS picks!