Four more teams can clinch a spot in the NFL playoffs when Week 16 of the 2022 season takes place over Christmas weekend. The Ravens, Bengals, Chargers and Giants all can earn a berth in the postseason in Week 16. Elsewhere around the league, the touchdown passing leaders in the AFC and NFC collide when Patrick Mahomes and the Chiefs meet Geno Smith and the Seahawks, and the 49ers look to win their eighth consecutive game.

Before you make any Week 16 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He entered the 2022 NFL season 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS and 8-3 on money-line plays last season for a profit of $1,552.

Hartstein also is 26-18-1 on his best bets this season, including 20-12-1 the past 11 weeks. Now, Hartstein has locked in three confident Week 16 NFL best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Titans to cover against the Texans. "Tennessee has already beaten the Texans by a touchdown with Malik Willis at quarterback," Hartstein told SportsLine.

Hartstein also has locked in two other spread picks, including a play on an underdog that will be "competitive." You ABSOLUTELY need to see his picks before betting on NFL Week 16!

So what are Hartstein's Week 16 NFL best bets? And which underdog that will be "competitive" is a must-play? ... Join SportsLine right now to see Larry Hartstein's Week 16 NFL best bets, all from the expert who entered the season up more than $3,700!