The Philadelphia Eagles and San Francisco 49ers collide in what could be a preview of the NFC Championship Game when the teams square off on Sunday at Lincoln Financial Field in Philadelphia. The Eagles (10-1) own the best record in the NFL and would be the No. 1 seed in the NFC playoff bracket if the season ended today. The 49ers (8-3) lead the NFC West and would be the No. 2 seed. Last season Philadelphia routed San Francisco in the NFC Championship Game, 31-7.

Kickoff is scheduled for 4:25 p.m. ET. San Francisco is a 2.5-point favorite in the latest 49ers vs. Eagles odds, while the over/under for total points scored is 47.5.

The game is one of 13 on the NFL schedule for Week 13, but which teams should you target with your NFL bets? Before you make any Week 13 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. Those selections form the basis of his weekly SportsLine NFL best bets, which are 58-39-2 since the start of last season, including a perfect 3-0 record last week.

Now, Hartstein has locked in three confident Week 13 NFL best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Lions to cover against the Saints. "Detroit DC Aaron Glenn ... coached alongside [Saints coach Dennis] Allen for five years in New Orleans, so it's likely Lions OC Ben Johnson knows how to attack this defense," Hartstein told SportsLine.

Hartstein also has locked in two other confident Week 13 NFL picks, including a team to cover in a "tight, low-scoring game." You ABSOLUTELY need to see his picks before betting on NFL Week 13.

So what are Hartstein's Week 13 NFL best bets? And what team that covers in a low-scoring game is a must-back? ... Join SportsLine right now to see Larry Hartstein's Week 13 NFL best bets, all from the expert who went 53-34-3 in the SuperContest last year!