The NFL Week 1 schedule features several intriguing matchups with no teams favored by double-digits in the latest Week 1 NFL odds. The Sunday NFL slate features 13 games, including Rams vs. Lions (-4.5) on Sunday Night Football. Among the most notable matchups during the day are Cowboys vs. Browns (-2.5), Broncos vs. Seahawks (-6), Dolphins vs. Jaguars (+3.5), and Titans vs. Bears (-4). With so many games on the schedule, there will be plenty of opportunity to cash in on free-to-play sites like PrizePicks, Underdog Fantasy, Sleeper, and DraftKings Pick 6. 

Before making your NFL prop picks and parlay lineups on sites like PrizePicks, Underdog Fantasy, Sleeper, and DraftKings Pick6 for Week 1, you NEED to see SportsLine's proven computer simulation model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 181-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 35-21 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

For Week 1, one of the model's top NFL prop picks is Vikings wide receiver Justin Jefferson going over 82.5 receiving yards. In fact, the model is projecting Jefferson to finish with 101 receiving yards on Sunday.

The model is also targeting an under-the-radar player who could go off for MASSIVE numbers in a DREAM matchup! This pick could be the difference between winning your parlays, tournaments, and cash games, or going home with nothing! You ABSOLUTELY need to see who it is before locking in any prop lineup cards of your own.

What are the top NFL prop picks for Week 1, and which players should you target when building parlay lineup cards? ... Join SportsLine now to see the top picks, predictions, best bets, and parlays for sites like PrizePicks, Sleeper, DraftKings Pick6, and Underdog Fantasy, all from SportsLine's proven computer simulation model, and find out!