The 2022 NFL season kicks off with 16 Week 1 games, including Broncos quarterback Russell Wilson returning to the Pacific Northwest to face his former team, the Seahawks. Wilson spent 10 seasons with the Seahawks, winning the Super Bowl in the 2013 season, before being traded to the Broncos in March. Other key NFL matchups include the Cowboys and Buccaneers squaring off in a rematch of the Week 1 classic from last season, and Panthers quarterback Baker Mayfield facing his former team, the Browns. 

Before you make any Week 1 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2022 NFL season, he is 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS and 8-3 on money-line plays last season for a profit of $1,552. His picks are available only at SportsLine and on the Early Edge.

Now, Hartstein has locked in three confident Week a NFL best bets. If you successfully parlay his picks, you're looking at a payout of 6-1.

We can tell you Hartstein loves the Chargers (-3) to cover against the Raiders. "The Raiders made a big splash adding Davante Adams, but the Chargers returned every key weapon," he told SportsLine.

Hartstein also has locked in two other spread picks, including one play fading a team that "could struggle initially." You ABSOLUTELY need to see his picks before betting on NFL Week 1.

So what are Hartstein's Week 1 best bets? And which team is a MUST-FADE? ... Join SportsLine right now to see Larry Hartstein's Week 1 NFL best bets, all from the expert who is up more than $3,700!