Seattle quarterback Geno Smith has the highest completion percentage in the NFL and has thrown for the sixth-most yards this season. Should he lead your NFL DFS lineups on Thursday Night Football against the 49ers? San Francisco wide receiver Deebo Samuel has an ankle injury as well, and his absence could impact the NFL DFS player pool. Before making your NFL DFS picks for 49ers vs. Seahawks, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

This year, he's already won the DraftKings Millionaire Maker twice and the FanDuel Million once! Now, McClure has turned his attention to 49ers vs. Seahawks and locked in his top daily Fantasy football picks.

We can tell you Seahawks receiver Tyler Lockett is one of McClure's top NFL DFS picks for Thursday Night Football. Part of McClure's optimal NFL DFS strategy also includes stacking McCaffrey with San Francisco quarterback Brock Purdy. The rookie impressed last week in his first career start against Tampa Bay following an injury to Jimmy Garoppolo in Week 13. Purdy helped engineer a convincing win and threw for 185 yards with two passing touchdowns and another score on the ground.

McClure is also targeting a player who could go off for MASSIVE numbers on Thursday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Seahawks vs. 49ers on Thursday Night Football? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!