The Week 5 NFL schedule opens with Russell Wilson, Jerry Jeudy, Courtland Sutton and the Denver Broncos hosting Matt Ryan, Michael Pittman, and the Indianapolis Colts on Thursday Night Football. All-Pro running back Jonathan Taylor (ankle) has been ruled out, opening the door for Nyheim Hines, Phillip Lindsay, and Deon Jackson to see increased workloads. In a game with plenty of offensive firepower on both sides, you'll need to find the right mix of players for your TNF NFL DFS picks. Before locking in any Broncos vs. Colts Showdown NFL DFS lineups for Thursday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

In Week 1 Monday Night Football, Kaylor listed Denver wide receiver Jerry Jeudy as one of his top Showdown DFS picks and the former Alabama star was the highest scoring fantasy player in the game. In Week 2 MNF, Kaylor called for a huge night from Buffalo wide receiver Stefon Diggs and he delivered 12 receptions for 148 yards and three touchdowns. In Week 3 TNF, Kaylor dominated with the Cleveland duo of Amari Cooper and Nick Chubb. In Week 3 MNF, he was all over Dallas wide receiver CeeDee Lamb, who was the highest scorer in the game. Then, in Week 4 MNF, his top two picks were 49ers wide receiver Deebo Samuel and Rams wide receiver Cooper Kupp, who both posted massive numbers. 

Now, Kaylor has turned his attention to Colts vs. Broncos on Week 5 Thursday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for the Broncos-Colts TNF matchup is Denver quarterback Russell Wilson. "With Javonte Williams out for the year, and Melvin Gordon having ball security issues, it's hard for me to see Denver leaning on its rushing attack against Indianapolis. Couple that with Wilson showing more inclination to make plays with his legs in the Broncos' last two games and you have the makings of a highly productive fantasy night for the future Hall of Famer on Thursday Night Football."

Kaylor is also targeting another under-the-radar option for TNF who could post HUGE numbers and carry your lineups to victory on Thursday night. This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Broncos vs. Colts on FanDuel and DraftKings? And which player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!