The Week 3 NFL schedule features a Sunday Night Football matchup pitting Denver Broncos quarterback Russell Wilson against a team he very familiar with, the San Francisco 49ers. Wilson is 17-4 all-time against the 49ers, but this will be his first time facing them as a member of the Broncos. For San Francisco, Jimmy Garoppolo will get the start after Trey Lance suffered a season-ending ankle injury. Before locking in any NFL DFS lineups for Sunday Night Football on sites like DraftKings and FanDuel, you NEED to see what Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

In the Broncos vs. Seahawks Week 1 Monday Night Football matchup, Kaylor listed Denver wide receiver Jerry Jeudy as one of his top Showdown DFS picks. The result: Jeudy hauled in 4 passes for 102 yards and a touchdown and was the highest scoring fantasy player in the game.

In the Week 2 Monday night double-header, Kaylor called for a huge night from Buffalo wide receiver Stefon Diggs. The two-time Pro Bowler would go on to catch 12 passes for 148 yards and 3 touchdowns, and was the highest scoring player DFS player on the slate.

In the Browns-Steelers Week 3 Thursday Night Football matchup, Kaylor was all over running back Nick Chubb and wide receiver Amari Cooper. Both players went off, scoring well over 20 DFS points each. 

Now, Kaylor has turned his attention to Broncos vs. 49ers on Week 3 Sunday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for the 49ers-Broncos SNF matchup is San Francisco All-Pro tight end George Kittle. The three-time Pro Bowler is making his first start of the season after missing two games with a groin injury, and Kaylor is expecting him to make splash on Sunday Night Football. "Denver has struggled against elite tight ends and with Justin Simmons on IR, I expect that to continue on Sunday night. The best comparison in my eyes is Travis Kelce, and he has owned the Broncos in recent years. Add in Jimmy Garoppolo as the 49ers starting quarterback and you have the makings of a huge fantasy night for Kittle in his first action of the season."

Kaylor is also targeting another under the radar option for SNF who could post HUGE numbers and carry your lineups to victory on Thursday night. This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for 49ers vs. Broncos on FanDuel and DraftKings? And which player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!