The 2022 NFL season has finally arrived and the opening Sunday features several matchups between quarterbacks who will be very popular in NFL DFS lineups. Week 1 will see Patrick Mahomes' Chiefs face Kyler Murray's Cardinals as well as Derek Carr, now equipped with Davante Adams, in a divisional battle against Justin Herbert and the Chargers.

Before you set your Week 1 NFL DFS lineups, you NEED to hear what SportsLine daily Fantasy expert Mike McClure has to say.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top one percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

We can tell you one of McClure's top NFL DFS picks for Week 1 is Panthers running back Christian McCaffrey. Part of McClure's optimal NFL DFS strategy includes rostering Chiefs tight end Travis Kelce at $6,600 on DraftKings and $8,000 on FanDuel. Kelce scored seven touchdowns over his last six regular and postseason games last year and should be an even bigger focal point in the Chiefs offense with Tyreek Hill off to Miami.

McClure is also targeting a player who could go off for MASSIVE numbers in Week 1! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who they are before locking in any lineups.

What are the top NFL DFS picks for Week 1? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!