For the third time in four years, the Major League Soccer All-Stars will take on the Liga MX All-Stars on Wednesday in the 2024 MLS All-Star Game at Lower.com Field in Columbus, Ohio. This format of the All-Star Game was introduced in 2021 and repeated a year later, with the MLS All-Stars defeating the Mexican side on penalties in Los Angeles and following with a 2-1 victory in Saint Paul, Minn. Last season, the MLS All-Stars were trounced 5-0 by Arsenal of the English Premier League in Washington D.C.

Kickoff is set for 8 p.m. ET. The MLS is the -135 favorite (risk $135 to win $100) in the latest MLS All-Stars vs. Liga MX All-Stars odds, while Liga MX is a +270 underdog. A 90-minute draw is priced at +320, and the over/under for total goals scored is 3.5 (For more soccer coverage, click here).

Before you lock in any Liga MX All-Stars vs. MLS All-Stars picks or predictions, you NEED to see what proven soccer expert Brandt Sutton has to say.

Sutton, a former collegiate soccer player, has been SportsLine's top soccer editor for more than six years. He has followed soccer closely for much longer and factors in managerial tactics, projected lineups and past performances to make the most-informed decisions possible, keeping his finger on the pulse of the game all over the globe.

Sutton was SportsLine's top soccer expert in 2022 with a 165-130-2 mark with his soccer picks, returning nearly $2,200 for $100 players. He was also profitable across multiple leagues in 2023, including the English Premier League, UEFA Champions League, FA Cup, Europa League and more.. 

Sutton knows that while the MLS All-Stars won't have Inter Miami superstar Lionel Messi (injury) or MLS' leading scorer Cristian Arango of Real Salt Lake (suspension), it still has some dangerous offensive weapons in its roster. One of them is D.C. United striker Christian Benteke, a two-time All-Star who is tied for second in scoring this season with 16 goals. Benteke is even with LAFC winger Denis Bouanga, who led MLS in 2023 with 20 tallies and also will be making his second All-Star Game appearance.

The expert also has taken into account that the Mexican All-Stars should have an advantage regarding stamina, as the new Liga MX season started just a few weeks ago. Two players who are among the top scorers in Liga MX thus far are on the All-Star roster, as midfielder Cesar Huerta of Pumas UNAM and Tigras UANL forward Andre-Pierre Gignac both have netted a pair of tallies. Meanwhile, forward Salomon Rondon of CF Pachuca shared the Clausura 2024 lead with eight goals.

For Wednesday, Sutton has taken an in-depth look at the MLS All-Stars vs. Liga MX All-Stars matchup. He has released a confident best bet and is offering a full breakdown of the 2024 MLS All-Star Game. You ABSOLUTELY need to see his picks and analysis before making any selections of your own. 

Who wins MLS All-Stars vs. Liga MX All-Stars on Wednesday, and where does all the betting value lie? ... Join SportsLine now to see Brandt Sutton's best bets for Liga MX All-Stars vs. MLS All-Stars, all from the soccer expert who has been profitable in multiple areas on his soccer picks.