The Tampa Bay Rays can take a commanding 2-0 lead on the Boston Red Sox in the American League Division Series when the two teams collide in Game 2 on Friday night at Tropicana Field in St. Petersburg, Fla. The Rays won Game 1 on Thursday night with a 5-0 victory over Boston, which had flown to South Florida after beating the Yankees in the Wild Card game on Tuesday night. Tampa Bay is the -140 favorite (risk $140 to win $100) in the latest Rays vs. Red Sox odds from Caesars Sportsbook while Boston is a +130 underdog. The Over/Under for total runs scored is 7.5. First pitch is at 7:02 p.m. ET. (See the latest lines for every game on our MLB odds page.)

Before making any Red Sox vs. Rays picks, check out the latest MLB playoff predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters the 2021 MLB playoffs with a 206-173 record on top-rated MLB money-line picks, returning well over $800. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

The model knows Tampa Bay lit up Chris Sale the last time the Rays faced him. On Sept. 6, Tampa Bay scored five runs on 10 hits in 3⅔ innings off Sale in an 11-10 victory. Those were the most hits and runs allowed by Sale this season.

The model also knows that Red Sox third baseman Rafael Devers is having a career season. Devers had a career-high 38 homers while also driving in 113 runs this season for Boston. He also has had a hot bat recently. Devers had two home runs in Sunday's regular-season finale against the Nationals and was 2-for-4 with a pair of walks and a run in the Wild Card win against the Yankees.

Now, it has set its sights on Rays vs. Red Sox. We can tell you it's leaning Over the total, and it also says one side of the money line hits in over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Game 2 of the ALDS and Rays vs. Red Sox? And which side of the money line hits over 60 percent of the time? ... Join SportsLine right now to find out which side of the Red Sox vs. Rays money line you should be all over on Friday, all from the model that is crushing its MLB picks in 2021!