After a soft opening Thursday, the 2022 MLB season really gets into a groove on Friday, with 13 games on the schedule. The day is scheduled to start with the storied Red Sox vs. Yankees rivalry at 1:05 p.m. ET. Nathan Eovaldi of the Red Sox and the Yankees' Gerrit Cole are set to square off, and many other top pitchers are on tap to start. Robbie Ray will take the mound for Seattle against the Twins (4:10 p.m. ET), while the Mets' Max Scherzer will face the Nationals team he play with for more than six seasons at 7:05 p.m. ET. Walker Buehler of the Dodgers and Miami's Sandy Alcantara are among the other notable starters Friday.

Charlie Morton leads the world champion Atlanta Braves against the Reds at 7:20 p.m. ET, and Jake Odorizzi starts for the AL champion Astros against the Angels at 9:38 p.m. ET. Atlanta is a -185 money-line favorite in the latest Braves vs. Reds odds from Caesars Sportsbook, and Houston is a +100 underdog in its matchup with L.A. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB moneyline picks in 2021, returning more than $700 for $100 players. Anyone following it has seen HUGE returns.

Now, the model has set its sights on the MLB schedule for Friday. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 8-1! The parlay doesn't start until 4 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Mets vs. Nationals matchup to go Over 8.5 runs (-120). But the model has three other picks, including a play on a home favorite that is winning in more than 70 percent of simulations! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which home favorite is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of more than 8-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that went went 209-178 on top-rated moneyline picks last season!