The Cleveland Guardians (12-13) and the Toronto Blue Jays (16-11) square off in the second matchup of their four-game series on Friday night with first pitch set for 7:10 p.m. ET. The Guardians are on a three-game win streak, including a 6-5 win over Toronto on Thursday. On the other side, Toronto has dropped two of their last three games. 

Toronto is a -145 money-line favorite (risk $145 to win) in the latest MLB odds from Caesars Sportsbook, while Cleveland is a +125 underdog. First pitch is set for 7:10 p.m. ET. The game is one of 13 on the MLB schedule on Friday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 28-13 roll on top-rated MLB money-line picks through four weeks, returning over $1,100 for $100 players. Anyone following it has seen HUGE returns!

Now, the model has set its sights on the MLB schedule for Friday, May 6. Using its top picks for the day, the model has generated a four-team parlay that would pay over 16-1. The parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Guardians stay within the +1.5 run line against the Blue Jays, returning -150. But the model has three other picks, including backing TWO outright underdogs to win. You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which MLB teams should you back on Friday? And which plus-money pick should you be all over? Join SportsLine here to find out, all from the model that has crushed its top-rated MLB money-line picks this season.