The Tampa Bay Rays attempt to bounce back from a rare loss when they host the Houston Astros in the rubber game of their three-game series on Wednesday (6:40 p.m. ET) at Tropicana Field in St. Petersburg, Fla. The Rays won 20 of their first 23 games this season, including all 14 at home, before being blanked 5-0 on Tuesday. The home winning streak to begin the season was the longest in the major leagues since 1886, when the Detroit Wolverines won their first 18 home games.

For Wednesday, Tampa Bay is a -125 favorite in the latest Rays vs. Astros odds from Caesars Sportsbook, while Houston is a +105 underdog. The over/under for runs scored is 8.5. The game is one of eight on the MLB schedule for Wednesday evening. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it is on a 26-21 run dating back to the end of last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Wednesday and has generated a three-leg parlay that would pay well over 6-1. The parlay doesn't start until 6:35 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Los Angeles Dodgers (-140) to beat the Pittsburgh Pirates. But the model has two other picks, including a play on an underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of well over 6-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is on a 26-21 run on top-rated money-line picks!