The Cleveland Guardians will look to stay hot when they face the slumping Baltimore Orioles on Wednesday at Oriole Park at Camden Yards in Baltimore. The Guardians (51-26) have won seven straight games and own the best record in all of baseball. Meanwhile the Orioles (49-30) have lost five in a row and sit in second place in the AL East. Carlos Carrasco (3-6, 5.40 ERA) will take the mound for Cleveland and face off against Baltimore's Grayson Rodriguez (8-3, 3.82). First pitch is set for 6:35 p.m. ET.

The Orioles are -189 favorites (risk $189 to win $100) in the latest Orioles vs. Guardians odds, while the Guardians are +158 underdogs. The over/under for total runs scored is 9. The game is one of 16 on the MLB schedule for Wednesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 14 of the 2024 MLB season 42-31 (+248) on all-top rated MLB picks this season. Dating back to last season, it is on a 21-8 roll on top-rated run-line picks (+869). Anybody following has seen strong returns.

Now, the model has set its sights on the MLB schedule for Wednesday and has generated a three-leg parlay that would pay well over 5-1! The parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Cubs (+106) to beat the Giants. But the model has two other picks, including a play on an even bigger underdog in the National League! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which NL underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of well over 5-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is 42-31 on all top-rated MLB picks this season!