The Seattle Mariners will look to extend their winning streak to five games when they open a three-game set in Cleveland with the Guardians Friday night. Trade acquisition Luis Castillo will take the ball for Seattle. The former Reds ace has been exceptional since his arrival in the Pacific Northwest, pitching to a 2.88 ERA in 31 2/3 innings of work. Cleveland will counter with Zach Plesac (3-11, 4.39 ERA

Seattle is a -135 favorite in the latest Mariners vs. Guardians odds from Caesars Sportsbook while Cleveland is a +115 underdog. First pitch is set for 7:10 p.m. ET. The game is one of 15 on the MLB schedule for Friday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 309-266 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Season. Anybody who has followed the model has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Friday, Sept. 2 and has generated a four-leg parlay that would pay more than 8-1! The parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Guardians (+1.5, -155) to cover against the Mariners. But the model has three other picks, including a play on an underdog in a game play playoff implications! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of more than 8-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is on a 309-266 run on top-rated MLB money-line picks since the start of 2021!