The Seattle Mariners try to avenge a sweep at the hands of the Houston Astros when they meet Thursday as part of a 10-game MLB schedule. The Astros won three games in Seattle to kick off the season's second half, and the teams begin a four-game set at Minute Maid Park at 8:10 p.m. ET on Thursday. Meanwhile, the Guardians look to close out a three-game sweep of the Red Sox (7:10 p.m. ET), and Andrew Benintendi could make his Yankees debut against his former team, the Royals, at 7:05 p.m. ET.

Houston is the -140 favorite on the moneyline in the latest Mariners vs. Astros odds from Caesars Sportsbook. The Mariners are +118 underdogs, and the Over/Under for total runs scored is 8.5. With 10 games on the Thursday MLB schedule, there are plenty of opportunities for wagers, and you can cash in big if you combine your favorite picks in a parlay. (See up-to-date lines for every game on our MLB odds page.)

Before you make any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 284-243 on top-rated MLB money-line picks since the start of the 2021 season, returning over $400 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Thursday, July 28. Using its top picks for the day, the model has generated a four-leg parlay that would pay well over 16-1! The parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the sliding Giants (-140) to defeat the streaking Cubs in the opener of their four-game series at 9:45 p.m. ET. The model has three other picks, including an underdog that would pay almost 2-1. You ABSOLUTELY need to see these picks before locking in any MLB picks of your own.

So which underdog is a MUST-BACK on Thursday night? And what other clubs do you need to include in your parlay for a payout of well over 16-1? ... Join SportsLine right now to find out which picks you should be all over on Thursday, all from the model that is 284-243 on top-rated MLB money-line picks since the start of the 2021 season!