After eight meetings in the Rose Bowl when this game was a Pac-12 vs. Big Ten matchup, USC (2-0) and Michigan (2-1) are set to meet as Big Ten foes for the first time on Saturday at 3:30 p.m. ET on CBS and streamed live on Paramount+ (get 1/2 off first year of an annual plan through 9/22).

The Trojans are 5.5-point road favorites in the latest Michigan vs. USC odds, while the over/under for total points scored is 46.5, per SportsLine consensus. 

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We can tell you it is leaning Over the total, projecting 60 combined points. It also says one side of the spread hits well over 50% of the time! You ABSOLUTELY need to see it before locking in any college football picks.

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