After eight meetings in the Rose Bowl when this game was a Pac-12 vs. Big Ten matchup, USC (2-0) and Michigan (2-1) are set to meet as Big Ten foes for the first time on Saturday at 3:30 p.m. ET on CBS and streamed live on Paramount+ (get 1/2 off first year of an annual plan through 9/22).

The Trojans are 4.5-point road favorites in the latest Michigan vs. USC odds, while the over/under for total points scored is 44, per SportsLine consensus. Alex Orji will start at quarterback in place of Davis Warren for Michigan.

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