The Michigan State Spartans take on the Western Kentucky Hilltoppers at 7:30 p.m. ET on Saturday at Spartan Stadium. The Spartans are off to their best start since 2015 behind quarterback Payton Thorne. Meanwhile, No. 15 Michigan State is easily the biggest game that Western Kentucky will play all season.

Michigan State narrowly escaped with a 23-20 win against Nebraska last week, but are now the only 2-0 team in the Big Ten conference standings. The Hilltoppers finished the 2020 regular season with three consecutive wins, but are on the road against good teams in three of the next four weeks. The Spartans are favored by 10.5 points in the latest Michigan State vs. Western Kentucky odds from Caesars Sportsbook, and the over-under is set at 61.5. Before you make any Western Kentucky vs. Michigan State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Michigan State vs. Western Kentucky 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Michigan State vs. Western Kentucky? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!