The No. 3 Ohio State Buckeyes will go on the road for the first time this season when they face the Michigan State Spartans in their Big Ten opener on Saturday night. Ohio State has cruised to three blowout wins to open the season and is considered one of the national championship contenders. Michigan State is looking to bounce back from its first loss of the campaign after falling to Boston College last week. 

Kickoff is set for 7 p.m. ET on Saturday at Spartan Stadium. Ohio State is favored by 23.5 points in the latest Michigan State vs. Ohio State odds, while the over/under is 48.5 points, per SportsLine consensus. Before entering any Ohio State vs. Michigan State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

The model has simulated Michigan State vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread is the better value!

So who wins Michigan State vs. Ohio State and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!