Although the division title is out of play, the Seattle Mariners will look to stay in the Wild-Card race when they take on the Houston Astros in a key American League West matchup on Wednesday afternoon. Houston beat Seattle 4-3 on Tuesday to clinch their seventh division title in eight years, and fourth in a row. Seattle enters Wednesday 2.5 games out of the final Wild-Card spot.

First pitch is scheduled for 2:10 p.m. ET from Minute Maid Park in Houston. Seattle is the -133 money-line favorite (risk $133 to win $100) in the latest Mariners vs. Astros odds, while the Astors are +112 underdogs. The over/under for total runs scored is 7 in the latest MLB odds via SportsLine consensus. 

Before you make any Mariners vs. Astros picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. Entering the final full week the MLB regular season, it's on a 31-17 roll on top-rated run-line picks (+722) that dates back to last season. Anybody following has seen STRONG returns!

The model knows Houston third baseman Alex Bregman had his third multi-hit game in the past five games on Tuesday, going 2-for-4 with a home run in the division-clinching win over Seattle. In 143 games this season, Bregman is batting .257 with 28 doubles, two triples, 26 homers and 74 RBI. He was 3-for-4 with a homer and three RBI in a 9-8 loss to the Los Angeles Angels on Sunday. He has hit the Mariners well throughout his career, batting .271 with 27 doubles, four triples, 11 homers and 53 RBI.

The model also knows Seattle second baseman Jorge Polanco has been on fire and is a big reason why Seattle is still in the Wild Card hunt. He was 4-for-4 with a homer and two RBI in Tuesday's loss to the Astros. He has a five-game hitting streak. He was 3-for-5 with a double and an RBI in an 8-4 win at Texas on Saturday. He has owned Houston pitching throughout his career. In 36 career games against the Astros, he is hitting .320 with 10 doubles, two triples, nine homers and 23 RBI.

The model has simulated Mariners vs. Astros 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Mariners vs. Astros, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 31-17 roll on top-rated MLB run-line picks!