The LSU Tigers travel to Starkville to face the Mississippi State Bulldogs in an SEC matchup at 12 p.m. ET on Saturday. LSU is favored by 2.5 points at Caesars Sportsbook, while the Over-Under is set at 56 (see up-to-date odds for every game this week on our college football odds page). 

Before making any LSU vs. Mississippi State picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

The model knows LSU's defense has played quite well this season. The Tigers are allowing fewer than 300 yards of total offense per game, including strong metrics against both the run and pass. LSU is giving up only 110 yards per game on the ground, with opponents averaging 2.8 yards per carry. Through the air, the Tigers are holding opponents to a 58.7 percent completion rate, and LSU leads the SEC with 17 sacks.

The model also knows Mississippi State has a potent passing offense. The Bulldogs won the 2020 matchup between these two teams, setting an SEC record for passing yards along the way. Mississippi State also leads the SEC in passing yards per game (361) this season, with sophomore quarterback Will Rogers also leading the conference in completion rate (74.8 percent). The Bulldogs could lean on their pass-happy offense, with Rogers having more completions (122) than any quarterback in the country.

Now, it has set its sights on LSU vs. Mississippi State. We can tell you the model is leaning over the total, and it also says one side of the spread hits in 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins LSU vs. Mississippi State? And which side of the spread hits in 60 percent of simulations? ... Join SportsLine right now to find out which side of the LSU vs. Mississippi State spread you should be all over Saturday, all from the model on a roll on college football picks!