Two programs off to opposite starts to the 2022-23 college basketball season face off on Wednesday night when the Louisville Cardinals (0-9) host the Western Kentucky Hilltoppers (8-1). Louisville has been among the poorest shooting teams in the country this season, and has hit just 37.2% of their shots from the field this year. Western Kentucky won the matchup between the two sides last season, 82-72.

Tip-off from the KFC Yum! Center is set for 9 p.m. ET. The Hilltoppers are favored by 7.5 points in the latest Louisville vs. Western Kentucky odds from Caesars Sportsbook, and the over/under is set at 133. Before you make any Western Kentucky vs. Louisville picks and predictions, you HAVE to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 6 of the 2022-23 college basketball season on a strong 17-10 roll on all-top rated CBB picks, returning almost $300. Anybody who has followed it has seen profitable returns.

Now, it has simulated Louisville vs. Western Kentucky 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in just over 50 percent of simulations. You ABSOLUTELY need to see it before locking in your own picks.

Who wins Louisville vs. Western Kentucky? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks, and find out!