The Louisville Cardinals (1-0) will get their first chance to notch a signature non-conference victory this season when they host the No. 12 Tennessee Volunteers (1-0) on Saturday afternoon. Louisville, which is playing under first-year coach Pat Kelsey, opened the season with a 93-45 win over Morehead State on Monday. Tennessee is coming off a comfortable win of its own, beating Gardner-Webb in an 80-64 final. 

Tipoff is set for noon ET on Saturday at the KFC Yum! Center in Louisville. Louisville is favored by 1.5 points in the latest Louisville vs. Tennessee odds, while the over/under is 154 points, per SportsLine consensus. Before entering any Tennessee vs. Louisville picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters the 2024-25 season on a 153-110 roll (+1891) on all top-rated college basketball picks dating back to 2023. Anyone following has seen huge returns.

The model has simulated Louisville vs. Tennessee 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 90% of simulations!

So who wins Tennessee vs. Louisville? And which side of the spread hits over 90% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!