An ACC battle is on tap between the Louisville Cardinals and the Pittsburgh Panthers at 8 p.m. ET on Saturday at Cardinal Stadium. Louisville is 3-3 overall and 1-1 at home, while Pitt is 4-2 overall and 1-0 on the road. Both teams last played in Week 6 when the Cardinals defeated Virginia 34-17 and the Panthers beat Virginia Tech 45-29. The Cardinals are favored by 2.5 points in the latest Louisville vs. Pittsburgh odds from Caesars Sportsbook, and the over/under is set at 55.

Before you make any Pittsburgh vs. Louisville picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns!

Now, it has simulated Louisville vs. Pittsburgh 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Pittsburgh? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.