The No. 10 Louisville Cardinals will try to wrap up an impressive regular season with a victory when they face the Kentucky Wildcats in a rivalry battle on Saturday afternoon. Louisville is riding a four-game winning streak and has already clinched a spot in the ACC title game. Kentucky has lost five of its last six games, but it has won four consecutive games between these teams. 

Kickoff is set for noon ET on Saturday at L&N Federal Credit Union Stadium. Louisville is favored by 8 points in the latest Louisville vs. Kentucky odds, while the over/under is 50.5 points, per SportsLine consensus. 

Before entering any Kentucky vs. Louisville picks, you NEED to see the college football predictions from the model at SportsLine.

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The model has simulated Louisville vs. Kentucky 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits more than 50% of the time. 

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