The Louisville Cardinals will take on the DePaul Blue Demons at 8 p.m. ET on Friday at the KFC Yum! Center. The Cardinals are 6-2 overall and 3-1 at home, while DePaul is 7-1 overall and 0-0 on the road. The Cardinals are favored by 7.5 points in the latest Louisville vs. DePaul odds from Caesars Sportsbook, and the over-under is set at 146. Before you make any DePaul vs. Louisville picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Louisville vs. DePaul 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. DePaul? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!