The Indiana Pacers host the Los Angeles Lakers in a Thanksgiving Eve matchup at 7 p.m. ET on Wednesday. Indiana is favored by five points at Caesars Sportsbook, while the Over-Under is set at 217 (see up-to-date odds for every game this week on our NBA odds page). Before making any Lakers vs. Pacers picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 6 of the 2021-22 NBA season up over $1,200 on all top-rated NBA picks this season. It's also on a stunning 115-76 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen HUGE returns.

The model knows the Lakers are strongly above-average in several key areas. Los Angeles is a top-10 team in field goal shooting at 46.1 percent, with the Lakers also shooting 34.8 percent from three-point range. The Lakers land in the top ten in both free throw volume (20.7 attempts per game) and assists (23.9 per game), with more than enough individual shot creation. Los Angeles is also creating a turnover on well over 15 percent of defensive possessions, with the Lakers blocking 6.1 shots per game. Indiana struggles to get to the free throw line as well, potentially giving Los Angeles an important edge.

The model also knows the Pacers are out-scoring opponents by 1.6 points per 100 possessions this season. Indiana is shooting a blistering 54 percent on two-point attempts, with top-10 marks in field goal shooting and offensive rebound rate. The Pacers are also limiting opponents to just 1.06 points per possession in 2021-22, with the No. 1 mark in the NBA in both two-point defense (48.8 percent) and blocked shots (6.8 per game). Indiana can also create turnovers in this matchup, with the Lakers ranking in the bottom three of the league in committing more than 16 giveaways per game.

Now, it has set its sights on Lakers vs. Pacers. We can tell you the model is leaning under the total, and it also says one side of the spread hits in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Lakers vs. Pacers? And which side of the spread hits in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Lakers vs. Pacers spread you should be all over Wednesday, all from the model on a roll on NBA picks!