The Chicago Bulls host the Los Angeles Lakers in a cross-conference NBA matchup at 8 p.m. ET on Wednesday. For this game, SportsLine consensus lists the Lakers as 4-point favorites, while the over/under is 224 (see up-to-date odds for every game this week on our NBA odds page). 

LeBron James (calf) and Anthony Davis (ankle) are listed as questionable for Los Angeles, with Zach LaVine (foot) ruled out for Chicago.

Before making any Lakers vs. Bulls picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five-plus seasons. The model enters Week 9 of the 2023-24 NBA season on a sizzling 101-52 roll on all top-rated NBA picks dating back to last season, returning well over $4,000. Anyone following it has seen HUGE returns!

The model knows the Lakers have a stout defense. Los Angeles is allowing only 111.7 points per 100 possessions this season, ranking in the top eight of the NBA. The Lakers are leading the league in allowing only 18.8 free throw attempts per game, and Los Angeles has top-eight metrics in other key categories. That includes opponent shooting and defensive rebound rate, with the Lakers also facing a below-average Bulls offense.

The model also knows the Bulls have improved recently. Chicago is 6-3 in the last nine games, scoring 1.19 points per possession in that sample. Standout forward DeMar DeRozan is averaging 24.1 points and 6.6 assists per game in December, and the Bulls lead the NBA in turnover avoidance. Chicago commits only 11.9 turnovers per game, and Los Angeles is allowing almost 14 3-pointers per game to opponents.

Now, it has set its sights on Lakers vs. Bulls. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in almost 60% of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Lakers vs. Bulls? And which side of the spread hits in almost 60% of simulations? ... Join SportsLine right now to find out which side of the Lakers vs. Bulls spread you should be all over Wednesday, all from the model on a roll on NBA picks!