The New York Knicks look to avoid a third consecutive loss when they return from a seven-game road trip to host the Portland Trail Blazers on Wednesday. New York (28-40) has followed a three-game winning streak with back-to-back defeats, including a 110-107 setback at Brooklyn on Sunday that concluded its 3-4 trek. Portland (26-41) is coming off its fifth straight road loss, a 122-113 defeat at Atlanta on Monday.

Tipoff at Madison Square Garden is scheduled for 7:30 p.m. ET. New York is a 12.5-point favorite in the latest Knicks vs. Trail Blazers odds from Caesars Sportsbook, while the over-under for total points scored is 222 (see up-to-date odds for every game this week on our NBA odds page). 

Before making any Trail Blazers vs. Knicks picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model entered Week 20 of the 2021-22 NBA season on a stunning 74-47 roll on all top-rated NBA picks, returning almost $2,100. Anyone following it has seen HUGE returns.

The model knows New York is just 13-19 at home and has lost five straight on its own court. Julius Randle leads the Knicks with an average of 20.5 points and has bounced back from a disappointing 10-point performance against the Los Angeles Clippers on March 6. The 27-year-old power forward has scored at least 26 points in each of his four outings since that disappointing effort and made 17 3-pointers during that stretch after going 7-for-33 from beyond the arc over his previous nine contests.

The model also knows Portland is 9-23 on the road this season and has lost seven of its last eight overall games. However, Josh Hart is coming off his two best offensive performances since entering the NBA with the Los Angeles Lakers in 2017-18. The 27-year-old shooting guard set a career high with 44 points in the Trail Blazers' 127-118 home victory over Washington on Saturday and followed up with 31 in the loss at Atlanta two days later.

Now, it has set its sights on Knicks vs. Trail Blazers. We can tell you the model is leaning Under the total, and it also says one side of the spread hits almost 60 percent of the time! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Knicks vs. Trail Blazers? And which side of the spread hits almost 60 percent of the time? ... Join SportsLine right now to find out which side of the Trail Blazers vs. Knicks spread you should be all over Wednesday, all from the model on a roll on NBA picks!