The Kentucky Wildcats will take on the No. 25 Louisville Cardinals in the Governor's Cup at 3 p.m. ET on Saturday at Kroger Field. Louisville has won five of its last six games, including a 25-10 win over NC State last week. The Wildcats are favored by 3 points in the latest Kentucky vs. Louisville odds from Caesars Sportsbook, while the over/under is set at 43. 

Before you make any Louisville vs. Kentucky picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Kentucky vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Kentucky vs. Louisville? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!