We know that Kansas City is going to be a dangerous team with Patrick Mahomes at quarterback. But how will the Chiefs respond after choking away a 21-3 second-quarter lead against an inferior Bengals team at home in last season's AFC Championship Game? How will Kansas City's revamped receiving corps perform without Tyreek Hill? For once, Andy Reid's team faces a myriad of questions with Mahomes at the helm. JuJu Smith-Schuster, Marquez Valdes-Scantling and second-round rookie Skyy Moore will try to fill the receiver void, but the unit could be a work in progress. Fortunately, Mahomes has future Hall of Fame tight end Travis Kelce to help shoulder the load.

The NFL did the Chiefs no favors with their early season schedule. Kansas City will play five 2021 playoff teams in their first seven games and the other two opponents, the Chargers and Colts, each missed the postseason by losing in Week 18. It's possibly the most difficult opening slate any team will face this season. Kansas City's schedule has a few relatively easy two-week stretches but overall, it might be hard for the Chiefs to match their previous regular season win totals with Mahomes and Reid: 12, 14, 12, and 12. It also doesn't help that they play in what looks to be the most competitive division in football this year, the AFC West.

While the Chiefs remain a fairly solid bet to make the playoffs, a division title is no longer a lock. The 10.5 win over / under by Caesars Sportsbook offers value for those who think the Hill loss will or won't be significant. While Kansas City will be a team no one wants to face in the playoffs, home or away, +500 to win the AFC still seems a bit light considering the questions on offense. 

• More NFL futures: SportsLine Projection Model's best bets

Below, you'll find the Kansas City Chiefs 2022 schedule, win total and more futures odds from Caesars Sportsbook, followed by picks from top SportsLine NFL analysts Larry Hartstein and R.J. White. You'll also find three bets favored by the SportsLine Projection Model.

Entering the 2022 NFL season, Larry is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 ATS. He went 68-50 ATS (58 percent) and 8-3 on moneyline plays last season for a profit of $1,552. Over the past seven years, R.J.'s SuperContest picks are 329-250-21 (56.8 percent) and he consistently crushes the NFL: He went 445-378-24 on ATS picks from 2017-21, returning $2,542 to $100 players as SportsLine's No. 1 NFL expert in against the spread picks.

Kansas City Chiefs 2022 schedule

Week 1: at Arizona
Week 2: vs. Los Angeles Chargers (TNF)
Week 3: at Indianapolis
Week 4: at Tampa Bay (SNF)
Week 5: vs. Las Vegas (MNF)
Week 6: vs. Buffalo
Week 7: at San Francisco
Week 8: BYE
Week 9: vs. Tennessee (SNF)
Week 10: vs. Jacksonville
Week 11: at Los Angeles Chargers
Week 12: vs. Los Angeles Rams
Week 13: at Cincinnati
Week 14: at Denver (SNF)
Week 15: at Houston
Week 16: vs. Seattle (SAT)
Week 17: vs. Denver
Week 18: at Las Vegas

Kansas City Chiefs 2022 futures odds

Win Total Over: 10.5 (-115)
Win Total Under: 10.5 (-105)

Make Playoffs: -240
Miss Playoffs: +200

Win Division: +155
Win Conference: +500
Win Super Bowl: +1000

So will the Chiefs go over or under their win total for the 2022 season? And what other futures bets are worth making? ... Join SportsLine right now to see Larry Hartstein and R.J. White's Kansas City Chiefs 2022 futures picks, all from the acclaimed experts who have crushed the NFL for years!