This is shaping up as a weird week.

We have a coaching change and a pair of quarterback changes, one due to performance and one due to injury, with perhaps another one still to come in Las Vegas. There's no shortage of variables and uncertainty, but it's not entirely scaring me off some of these plays. It definitely makes some things more difficult to handicap, but I also believe the books have already reacted too strongly in some cases to the new information.

I had another strong showing in Week 5 and continue to navigate things fairly judiciously. Getting some teams back from the bye is intriguing, and I'll continue to wager on some of the divisional games as well.

Before you make your Week 6 picks, you'll want to see what NFL expert Jason La Canfora has to say. La Canfora has broken the games down and found a number of best bets, including a play on the Lions-Cowboys game worth jumping on. You NEED to see his analysis before locking in any NFL picks of your own. 

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What is La Canfora's play for Lions-Cowboys? And what are the rest of his NFL Week 6 picks? Join SportsLine right now to see all of Jason La Canfora's best bets!