A Big Ten battle is on tap between the Iowa Hawkeyes and the Indiana Hoosiers at 3:30 p.m. ET on Saturday at Kinnick Stadium. Iowa (6-2) ended last year second in the West Division, while Iowa (6-2) placed second in the East. These teams last played in 2018 where Iowa dominated on the way to a 42-16 victory.

The Hawkeyes are favored by 3.5 points in the latest Iowa vs. Indiana odds from Caesars Sportsbook. The over-under is set at 46. Before you make any Indiana vs. Iowa picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Iowa vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that hits in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Iowa vs. Indiana? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks. .. If you're already a member, see the picks below!