The Iowa State Cyclones are hoping to shake up the Big 12 standings on Saturday at 3:30 p.m. ET when they host No. 8 Oklahoma State at Jack Trice Stadium. Iowa State is 4-2 overall and 2-1 at home, while Oklahoma State is 6-0 overall and 2-0 on the road. The Cowboys came back last week against Texas for their sixth consecutive win this season, while the Cyclones' only losses this season have come against No. 11 Iowa and No. 20 Baylor.

Despite Oklahoma State coming in as a top-10 team in the AP Top 25 rankings, the Cyclones are favored by seven points in the latest Iowa State vs. Oklahoma State odds from Caesars Sportsbook, and the over-under is set at 47. In Oklahoma State's only two games this season as a road underdog, the Cowboys have covered the spread in each. Before you make any Oklahoma State vs. Iowa State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Iowa State vs. Oklahoma State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. 

So who wins Iowa State vs. Oklahoma State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.