Two teams looking for their first Big 12 wins meet on Saturday when the Iowa State Cyclones and the Kansas Jayhawks meet at 7 p.m. ET at Jack Trice Stadium. Iowa State is already looking to get its season back on track, while Kansas continues to trey and re-invent its program yet again in 2021.

Although its results are familiar to previous seasons, the Kansas offense has taken a big step forward from last season, and averages nearly 100 more yards per game so far. Iowa State has received the benefit of the doubt in the national rankings, but needs to come out of this week with a win. The Cyclones are favored by 34 points in the latest Iowa State vs. Kansas odds from Caesars Sportsbook, and the over-under is set at 57.5. Before entering any Kansas vs. Iowa State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Iowa State vs. Kansas 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Iowa State vs. Kansas? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!