After two one-year experiments at quarterback in Philip Rivers and Carson Wentz and a disastrous Week 18 collapse in Jacksonville to miss the playoffs, the Colts head into the 2022 season with a hope for stability at the position in the form of veteran signal-caller Matt Ryan. With Ryan's veteran leadership and elite running back Jonathan Taylor's dynamic skill set, the Colts shouldn't have much of a problem moving the ball this season despite a subpar group of pass-catchers. Defensively, despite the loss of coordinator Matt Eberflus, who became the Bears' new head coach, Indianapolis should field a plus unit.

Playing in arguably the weakest division in the league, the Colts only have Tennessee to truly contend with for the AFC South title. Assuming Indianapolis can sweep their opening two games on the road, in one of the easiest back-to-back road slates any team will face all season, they have a chance to establish themselves as a big player in the AFC with home games against Kansas City and division rival Tennessee in the third and fourth weeks. Another advantage of Indy's schedule is two layup games to end the season against the likely non-contending Giants and Texans.

Assuming Ryan and Taylor stay healthy, there's decent value in Indianapolis to win the AFC South at -115. While the Colts have the potential to make a run this season, there is so much competition in the AFC that +1300 to win the conference almost looks a bit too light. This teams seems capable of making a second-round playoff appearance, which I'm sure most Colts fans would welcome after last year's Week 18 collapse.

• More NFL futures: SportsLine Projection Model's best bets

Below, you'll find the Indianapolis Colts 2022 schedule, win total and more futures odds from Caesars Sportsbook, followed by picks from top SportsLine NFL analysts Larry Hartstein, R.J. White and Alex Selesnick. You'll also find three bets favored by the SportsLine Projection Model.

Entering the 2022 NFL season, Larry is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 ATS. He went 68-50 ATS (58 percent) and 8-3 on moneyline plays last season for a profit of $1,552. Over the past seven years, R.J.'s SuperContest picks are 329-250-21 (56.8 percent) and he consistently crushes the NFL: He went 445-378-24 on ATS picks from 2017-21, returning $2,542 to $100 players as SportsLine's No. 1 NFL expert in against the spread picks. Selesnick (aka PropStarz) specializes in MLB, NFL and NBA prop betting, where he implements a combination of research, statistical analysis and mathematical modeling to deliver profitable long-term results.

Indianapolis Colts 2022 schedule

Week 1: at Houston
Week 2: at Jacksonville
Week 3: vs. Kansas City
Week 4: vs. Tennessee
Week 5: at Denver (TNF)
Week 6: vs. Jacksonville
Week 7: at Tennessee
Week 8: vs. Washington
Week 9: at New England
Week 10: at Las Vegas
Week 11: vs. Philadelphia
Week 12: vs. Pittsburgh (MNF)
Week 13: at Dallas (SNF)
Week 14: BYE
Week 15: at Minnesota (SAT or SUN)
Week 16: vs. Los Angeles Chargers (MON)
Week 17: at New York Giants
Week 18: vs. Houston

Indianapolis Colts 2022 futures odds

Win Total Over: 9.5 (-135)
Win Total Under: 9.5 (+115)

Make Playoffs: -160
Miss Playoffs: +140

Win Division: -115
Win Conference: +1300
Win Super Bowl: +2500

So will the Colts go over or under their win total for the 2022 season? And what other futures bets are worth making? ... Join SportsLine right now to see Larry Hartstein and R.J. White's Indianapolis Colts 2022 futures picks, all from the acclaimed experts who have crushed the NFL for years!