The second-ranked Ohio State Buckeyes look to win their 27th consecutive game over the Indiana Hoosiers when they meet in a key Big Ten Conference East Division matchup on Saturday. The Buckeyes (9-0, 6-0), one of four remaining unbeaten teams, are coming off a 21-7 win at Northwestern last week. The Hoosiers (3-6, 1-5), who have lost 13 consecutive games in October and November, are coming off a 45-14 loss to Penn State. This will be the first time Indiana has been a 40-point underdog since at least 1995.

Kickoff from Ohio Stadium in Columbus, Ohio, is set for noon ET. The Buckeyes are listed as 40-point favorites in the latest Indiana vs. Ohio State odds from Caesars Sportsbook, while the over/under for total points scored is 61. (See up-to-date odds for every game this week on our college football odds page.) 

Before you make any Indiana vs. Ohio State picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns!

The model knows after being slowed at Northwestern last week, the Buckeyes look to crank up the offense once again, led by junior quarterback C.J. Stroud. For the season, he has powered the Buckeyes by completing 169 of his 249 passes (67.9%) for 2,453 yards and 29 touchdowns. He has been picked off just four times, and has a rating of 185.8. He has thrown for at least 300 yards in four games, including a 21-of-26 performance (80.8%) for 361 yards and six touchdowns with one interception in the 49-20 win at Michigan State on Oct. 8.

The model also knows the Hoosiers have played Ohio State tough the last decade, including three games decided by one score. After missing last week's game due to injury, junior quarterback Connor Bazelak will make his return. For the season, he has completed 208 of his 379 passes (54.9%) for 2,099 yards and 12 touchdowns with nine interceptions. He has also rushed for a score.

Now, the model has set its sights on Indiana vs. Ohio State. We can tell you it is leaning Over the total, and it also says one side of the spread hits almost 60% of the time! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Indiana vs. Ohio State? And which side of the spread hits almost 60% of the time? ... Join SportsLine right now to find out which side of the Indiana vs. Ohio State spread you should be all over Saturday, all from the model on a roll on college football picks!