The No. 7 Michigan Wolverines welcome the Indiana Hoosiers to Ann Arbor for a Big Ten showdown at 7:30 p.m. ET on Saturday. Michigan is favored by 20.5 points at Caesars Sportsbook, while the Over-Under is set at 50.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Indiana vs. Michigan picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Indiana has battled injuries in 2021, but the Hoosiers have talent and a 2020 win over Michigan. On offense, Stephen Carr, Peyton Hendershot and Ty Fryfogle form a strong trio at the skill positions. Defensively, Indiana has been very strong against the run, allowing only 126.1 yards per game and 3.8 yards per carry. That is crucial against a Michigan offense that leans on the ground game, and it provides optimism for the Hoosiers.

The model also knows Michigan is very good on both sides of the ball. On defense, the Wolverines are allowing only 17.1 points per game, a top-10 figure in the country. Michigan has a disruptive pass rush, headlined by Aidan Hutchinson, and the Wolverines are above-average against both the run and pass. On offense, Michigan is the best team in the Big Ten on the ground, rushing for nearly 240 yards per game on 5.3 yards per carry. The Wolverines are generating 37.1 points per game in 2021, and Michigan is a balanced, talented squad.

Now, it has set its sights on Indiana vs. Michigan. We can tell you the model is leaning over the total, and it also says one side of the spread hits more than 50 percent of the time! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Indiana vs. Michigan? And which side of the spread hits more than 50 percent of the time? ... Join SportsLine right now to find out which side of the Indiana vs. Michigan spread you should be all over Saturday, all from the model on a roll on college football picks!