A Big Ten battle takes place when the Indiana Hoosiers (0-0) host the Illinois Fighting Illini (1-0) on Friday night at 8 p.m. ET. Indiana is favored by one point at Caesars Sportsbook, while the over/under is set at 46.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Illinois vs. Indiana picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

The model knows Illinois is a run-first offense. This unit will look to implement its ground game to showcase its physicality and toughness. The Fighting Illini displayed this rushing attack in their Week 0 victory over Wyoming last week. They logged 269 rushing yards along with three rushing scores. This run game was led by junior running back Chase Brown, who had 19 carries for 156 yards and two touchdowns. 

The model also knows Indiana trots out a new tandem at running back. Transfers Shaun Shivers and Josh Henderson will be the main ball-carriers for the Hoosiers. Shivers is a shifty tailback with good agility and acceleration. Meanwhile, Henderson is a physical runner who averages 5.1 yards per carry during his college career. During the 2021 campaign, Indiana logged 114.5 rushing yards per game.

Now, it has set its sights on Illinois vs. Indiana. We can tell you the model is leaning Under the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

So who wins Illinois vs. Indiana? And which side of the spread hits well over 50% of the time? Join SportsLine now to find out, all from the model that has crushed its top-rated college football picks against the spread!