The Illinois Fighting Illini will take on the Charlotte 49ers at noon ET on Saturday at Memorial Stadium. The Fighting Illini are 1-4 overall and 1-2 at home, while Charlotte is 3-1 overall and 0-1 on the road. The Fighting Illini are favored by 9.5 points in the latest Illinois vs. Charlotte odds from Caesars Sportsbook, and the over-under is set at 54.5. 

Before making any Charlotte vs. Illinois picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Illinois vs. Charlotte 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Illinois vs. Charlotte? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks. .. If you're already a member, see the picks below!