Houston (3-1) is the only team with an American Athletic Conference win this season and could improve to 2-0 in conference play on Friday. The Cougars will face a Tulsa (1-3) team that secured its first victory of 2021 over Arkansas State last week. Tulsa is favored by 3.5 points in the latest Houston vs. Tulsa odds at Caesars Sportsbook, and the Over-Under for total points is set at 54. Kickoff from H.A. Chapman Stadium is set for 7:30 p.m. ET.

Before you make any Houston vs. Tulsa picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Houston vs. Tulsa 10,000 times, and the results are in. We can tell you that the model is leaning Under the total, and it's also generated a point-spread pick that has all the value. You ABSOLUTELY need to see it before locking in your own picks. 

So who wins Houston vs. Tulsa? And which side of the spread has all the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.