Get ready for a Big 12 battle as the Houston Cougars and the TCU Horned Frogs will face off on Saturday. This will be Houston's first Big 12 game after spending the last 10 years in the AAC. Both teams are 1-1, with Houston coming off a loss to Rice, while TCU enters in off a victory versus Nicholls State.

Kickoff is at 8:00 p.m. ET from TDECU Stadium. The Horned Frogs are favored by 7.5 points in the latest Houston vs. TCU odds, and the over/under is 64.5 points. Before entering any TCU vs. Houston picks, you'll want to see the college football predictions from the model at SportsLine.

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The model has simulated Houston vs. TCU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits in over 60% of simulations. You can only see the pick at SportsLine.

So who wins TCU vs. Houston, and which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks. If you're already a member, see the picks below!