The Memphis Grizzlies' undefeated start to the 2021-22 NBA season came to an end against the Los Angeles Lakers on Sunday, and they'll try their luck against another Western Conference rival on Wednesday. The Portland Trail Blazers will host Memphis at the Moda Center and could rebound from Monday's blowout loss to the Los Angeles Clippers with a win. Caesars Sportsbook lists the Trail Blazers as 2.5-point favorites, and the Over-Under is set at 234. (see up-to-date odds for every game this week on our NBA odds page). Tip-off is set for 10 p.m. ET.

Before making any Grizzlies vs. Trail Blazers picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model finished up almost $600 on its top-rated picks last season and entered Week 2 of the 2021-22 NBA season on a stunning 103-68 roll on top-rated NBA picks against the spread. Anyone following it has seen HUGE returns!  

The model knows the Grizzlies have been terrible on defense. Memphis has the worst defensive rating (117.1) in the NBA and is giving up more than 118 points per game. That weakness could be detrimental to the visitors against a team with dynamic scorers.

The model also knows the Trail Blazers haven't quite hit their stride on offense. While Portland boasts a top-1o scoring offense, Damian Lillard is shooting less than 40 percent from the field and less than 10 percent from three. He'll have to bounce back to help his team keep up with the NBA's highest-scoring offense.

Now, it has set its sights on Grizzlies vs. Trail Blazers. We can tell you the model is leaning under the total, and it also says one side of the spread hits in more than 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Grizzlies vs. Trail Blazers? And which side of the spread hits in more than 50 percent of simulations? ... Join SportsLine right now to find out which side of the Lakers vs. Spurs spread you should be all over Wednesday, all from the model on a roll on NBA picks!