The New York Giants (1-4) travel to face the Buffalo Bills (3-2) on Sunday Night Football at Highmark Stadium. The Bills are coming off a loss in London, 25-20, to the Jacksonville Jaguars. The Giants have lost three games in a row, falling 31-16 to the Miami Dolphins last week. Quarterback Daniel Jones (neck) is out for New York.

Kickoff is at 8:20 p.m. ET. Buffalo is a 15-point favorite in the latest Giants vs. Bills odds while the over/under for total points scored is 43.5. Before you make any Giants vs. Bills picks or NFL predictions, you need to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has set its sights on Giants vs. Bills. We can tell you the model is leaning Over the point total, and it also says one side of the spread hits in nearly 60% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Giants vs. Bills on Sunday Night Football, and which side of the spread cashes almost 60% of the time? ... Join SportsLine right now to find out which side of the Giants vs. Bills spread is a MUST-BACK, all from the model on a 171-119 roll on NFL picks!