Week 3 of the NFL season begins on Thursday Night Football with a battle between NFC playoffs teams from a year ago. The New York Giants will visit the San Francisco 49ers, with kickoff from Santa Clara set for 8:15 p.m. ET. The 49ers are 10.5-point favorites, while the over/under is 44. Before you make any Giants vs. 49ers picks or any other NFL predictions, you NEED to see which side Micah Roberts is on.

Roberts has worked in the Las Vegas sportsbook industry for more than 20 years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He's also uniquely dialed into the 49ers, with a 17-5 run on picks involving San Francisco that has returned $1,150 to bettors! Anyone who has followed him is WAY UP.

Roberts knows the Giants have a top-10 passing defense so far this season. New York allowed only 187.5 passing yards per game in the first two weeks and was above-average in total defense, yielding only 322 total yards per game. In 2022, the Giants were also in the top five of the NFL in third down efficiency and red zone efficiency.

Roberts also knows San Francisco has won 12 straight regular season games and the offense is firing on all cylinders to begin the season. The 49ers are in the top five in scoring, averaging 30.0 points per game and scoring on 54.5% of possessions. San Francisco also leads the NFL in rushing touchdowns and yards per carry (5.6) through two weeks.

Now, Roberts has locked in another confident against the spread pick for Giants vs. 49ers. We can tell you he's leaning Over the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Giants vs. 49ers on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Giants vs. 49ers spread to jump on, all from the expert on a 17-5 run on San Francisco picks!