The Florida Gators take on the South Florida Bulls at 7:30 p.m. ET on Saturday at Florida Field at Ben Hill Griffin Stadium. The Gators are 1-1 overall and coming off of a stinging loss to Kentucky last weekend, while South Florida is 1-1 overall but will play its first road game of the season at The Swamp. Despite the long history of both programs, this weekend will be just the third time the two sides meet.

The Gators are favored by 24.5 points in the latest Florida vs. South Florida odds from Caesars Sportsbook, and the over/under is set at 59. Before you make any South Florida vs. Florida picks, you HAVE to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Florida vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations! You absolutely need to see it before locking in your own picks.

Who wins Florida vs. South Florida? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!